Agilent Extend-C18 3.5u 4.6x150mm 763953-902

The Agilent ZORBAX Extend‑C18 (part number 763953‑902) is a 4.6 x 150 mm, 3.5 µm reversed‑phase HPLC analytical column designed for separations that require stability at elevated pH. It uses the Extend‑C18 bonded phase chemistry to permit robust silica‑based separations up to about pH 11.5, improving retention and peak shape for basic compounds. Typical uses include method development and routine analysis of small molecules, peptides, and basic analytes where high‑pH mobile phases or LC/MS sensitivity are desirable.

Key Features:

• Separation Mode: Reversed Phase (C18, Extend‑C18)
• Chemistry: Extend‑C18 (bidentate/bonded C18 phase, endcapped)
• Particle Size: 3.5 µm
• Length: 150 mm
• Inner Diameter: 4.6 mm
• pH Range: 2.0–11.5
• USP Classification: L1

Advantages:

• Stable performance at high pH (up to ~11.5) enables improved retention and peak shape for basic analytes.
• Extend‑C18 bonding and double endcapping provide enhanced silica protection and extended column lifetime under demanding mobile‑phase conditions.
• High efficiency 3.5 µm packing delivers good resolution for method development and routine analyses.
• Suitable for LC/MS workflows with improved sensitivity for peptides and small molecules when high‑pH buffers are used.