Agilent Extend-C18 3.5u 4.6x75mm 766953-902

The Agilent ZORBAX Extend-C18 column (part number 766953-902) is a 4.6 x 75 mm, 3.5 µm reversed-phase HPLC column designed for routine and high-pH separations. It uses the Extend‑C18 stationary phase on 80 Å fully porous silica to provide high efficiency and robust peak shape for small molecules and peptides. The column is specified for pH 2–11.5 and is rated to 400 bar, making it suitable for methods that require alkaline mobile phases or elevated pressures.

Key Features:

• Dimensions: 4.6 mm ID × 75 mm length; particle size 3.5 µm.
• Stationary phase: ZORBAX Extend‑C18 on fully porous silica; pore size 80 Å.
• pH range: 2–11.5; maximum temperature 60 °C (pH 2–8) and 40 °C (pH 8–11.5).
• Pressure rating: 400 bar.
• USP designation L1; double endcapped; carbon load ~12.5%.

Advantages:

• High-pH stability (pH 2–11.5) enables separations of basic analytes and methods that require alkaline buffers.
• 3.5 µm particles with double endcapping deliver high efficiency and improved peak shape for small molecules and peptides.
• Manufacturer-rated 400 bar construction supports routine HPLC pressures and robust operation.
• Authorized distributor descriptions note improved LC/MS sensitivity for peptides/small molecules when avoiding TFA-containing mobile phases.